银河娱乐

校聘副教授，硕士生导师。2005年毕业于中国科学技术大学生命科学银河娱乐 ，获理学学士学位，2005年在中国科学技术大学生命科学银河娱乐 分子细胞遗传学实验室攻读博士学位，2011年获得遗传学博士学位。2012年，进入安徽医科大学任教至今，从事肿瘤放化疗敏感性的科研工作。参与了多项国家级基金资助的研究，主持国家自然科学基金1项。在SCI期刊公开发表学术论文16篇，其中通讯作者或第一作者论文3篇，参与编写学术专著1本。

1.       安徽省自然科学基金，面上项目(2208085MH249)，超甲基化导致的TRIM29低表达促进食管癌恶性进程的作用及分子机制研究，2022/01-2024/12，在研，主持。

2.       国家自然科学基金，面上项目(12275003)：射线品质调控connexin26和细胞焦亡在介导放射性皮肤损伤中的作用机制研究，2023.01-2026.12，在研，参与。

3.       安徽高校自然科学研究项目，重点项目(KJ2020A0147)，HSD17B6低表达促进肝癌发展的机制研究，2021/01-2022/12，结题，主持。

4.      国家自然科学基金，青年项目(81402327)：非整倍体在肿瘤细胞抗逆性和侵袭转移能力中的作用及其机制，2015/1 – 2017/12，结题，主持。

5.       国家自然科学基金，面上项目(30571030), p53在双核细胞进入有丝分裂和形成双极纺锤体中的作用和机制, 2006/01 – 2008/12，结题，参与。

6.       国家杰出青年基金 (30725013), 四倍体细胞多极分裂蛋白调控网络及其分子机制的研究, 2006/1 – 2011/12，结题，参与。

一作/通讯文章：

1.      Lei Lv ^#, Qinqin Wei ^#, Jianxiao Zhang ^#, Yitong Dong, Zhenglei Shan, Na Chang, Ye Zhao *, Po Bian *, Qiyi Yi *: IGF2BP3 Prevent HMGB1 mRNA Decay in Bladder Cancer and Development. Cellular & Molecular Biology Letters, 2024, 29(39)

2.      Qiyi Yi ^#, Yujia Zhao ^#, Ran Xia ^#, Qinqin Wei, Fengmei Chao, Rui Zhang, Po Bian *, Lei Lv *: TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750. Cell Death Discovery, 2023, 9(191)

3.      Qiyi Yi ^#, Youguang Pu ^#, Fengmei Chao, Po Bian *, Lei Lv *: ACAP1 Deficiency Predicts Inferior Immunotherapy Response in Solid Tumors. Cancers, 2022, 14(23).

4.      Tian Tian, Fu Hong, Zhiwen Wang, Jiaru Hu, Ni Chen, Lei Lv *, Qiyi Yi *: HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma. Cell Death Discovery, 2021, 7(341)

5.      Lei Lv ^#, Qinqin Wei ^#, Zhiwen Wang, Yujia Zhao, Ni Chen, Qiyi Yi *: Clinical and Molecular Correlates of NLRC5 Expression in Patients With Melanoma. Frontiers in Bioengineering and Biotechnology, 2021, 9:690186.

6.      Lei Lv, Yuliu Zhang, Yujia Zhao, Qinqin Wei, Ye Zhao, Qiyi Yi *: Effects of 1p/19q Codeletion on Immune Phenotype in Low Grade Glioma. Frontiers in Cellular Neuroscience, 2021, 15:704344.

7.      Lei Lv ^#, Yujia Zhao ^#, Qinqin Wei, Ye Zhao, Qiyi Yi *: Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. Cancer Cell International, 2020, 20(210)

8.      Qiyi Yi, Xiaoyu Zhao, Yun Huang, Tieliang Ma, Yingyin Zhang, Heli Hou, Howard J Cooke, Da-Qing Yang, Mian Wu, Qinghua Shi: p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells. PLoS One 2011, 6(11):e27304.

共一作/通讯文章：

1.      Fengmei Chao ^#, Yang Zhang ^#, Lei Lv, Yaqin Wei, Xiaoyan Dou, Na Chang, Qiyi Yi *, Ming Li *: Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1. International Journal of Nanomedicine, 2023, 18: 2989-3006

2.      Lingsuo Kong, Fei Gao, Fangfang Zhao, Ran Xia, Cifeng Cai, Weixin Wang, Dabing Huang, Zhenyu Li, Qiyi Yi *, Chunbao Zang *, Youguang Pu *: Profiling the m⁶A-regulated RNA expression patterns and alternative splicing features in esophageal carcinoma. Genes & Diseases, 2023, 10(5):1812-1815.

3.      Wulin Shan ^#, Chunyang Dai ^#, Huanhuan Zhang, Dan Han, Qiyi Yi *, Bairong Xia *: ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway. Cancers, 2022, 14(22): 5704

4.      Lei Lv ^#, Qiyi Yi ^#, Ying Yan ^#, Fengmei Chao, Ming Li *: SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer Metastasis via Activating AKT Signaling Pathway. Frontiers In Oncology, 2021, 11:682773.

5.      Youguang Pu ^#, Qiyi Yi ^#, Fangfang Zhao ^#, Haiyan Wang, Wenjing Cai, Shanbao Cai: MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene. Cancer Cell Int 2016, 16:64.

6.      易启毅 (2007)，细胞生物学荧光技术：原理和应用（主编：刘爱平），第十章 荧光原位杂交，中国科学技术大学出版社，中国，合肥

参与作者文章：

1.      Luo W, Zhang H, Liang X, Xia R, Deng H, Yi Q, Lv L, Qian L: DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10. Oncol Rep 2020, 43(5):1692-1704.

2.      Song B, Zhang Q, Yu M, Qi X, Wang G, Xiao L, Yi Q, Jin W: Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha. Oncol Lett 2017, 13(2):754-762.

3.      Xie J, Jiang J, Shi K, Zhang T, Zhu T, Chen H, Chen R, Qi L, Ding W, Yi Q et al: DNA damage in peripheral blood lymphocytes from patients with OSAHS. Sleep Breath 2014, 18(4):775-780.

4.      Xia M, Hu S, Fu Y, Jin W, Yi Q, Matsui Y, Yang J, McDowell MA, Sarkar S, Kalia V et al: CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin. J Allergy Clin Immunol 2014, 134(3):634-644 e610.

5.      Qi R, Jin W, Wang J, Yi Q, Yu M, Xu S, Jin W: Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1alpha expression. Oncol Rep 2014, 31(5):2399-2406.

6.      Hu Y, Xu S, Jin W, Yi Q, Wei W: Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells. Oncol Rep 2014, 32(4):1741-1747.

7.      Wang J, Yu M, Xiao L, Xu S, Yi Q, Jin W: Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro. Oncol Rep 2013, 30(2):917-924.

8.      Lv L, Zhang T, Yi Q, Huang Y, Wang Z, Hou H, Zhang H, Zheng W, Hao Q, Guo Z et al: Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle 2012, 11(15):2864-2875.

9.      Huang Y, Jiang L, Yi Q, Lv L, Wang Z, Zhao X, Zhong L, Jiang H, Rasool S, Hao Q et al: Lagging chromosomes entrapped in micronuclei are not 'lost' by cells. Cell Res 2012, 22(5):932-935.

10.   Hou H, Zhang Y, Huang Y, Yi Q, Lv L, Zhang T, Chen D, Hao Q, Shi Q: Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One 2012, 7(4):e35665.

11.   Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun Q et al: Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes. PLoS One 2012, 7(1):e29735.

12.   Huang Y, Hou H, Yi Q, Zhang Y, Chen D, Jiang E, Xia Y, Fenech M, Shi Q: The fate of micronucleated cells post X-irradiation detected by live cell imaging. DNA Repair (Amst) 2011, 10(6):629-638.

13.   Rao X, Zhang Y, Yi Q, Hou H, Xu B, Chu L, Huang Y, Zhang W, Fenech M, Shi Q: Multiple origins of spontaneously arising micronuclei in HeLa cells: direct evidence from long-term live cell imaging. Mutat Res 2008, 646(1-2):41-49.

1. 中华医学会核医学分会第二届全国教学比赛三等奖