银河娱乐

赵明霞，生物学博士，中国药理学会抗炎免疫药理专委会青年委员，中华中医药学会中药实验药理分会青年委员，International Immunopharmacology 杂志青年编委。博士毕业于南京大学生物学专业，2024年加入银河娱乐-银河国际 工作至今。主要研究中药活性成分作用靶点和功能蛋白的作用机制。相关研究成果已在Acta pharmaceutica Sinica B， Advanced Science, Journal of Molecular Cell Biology, Cell Death and Disease等SCI期刊上发表，其中第一作者（含共一）文章有6篇，其中中科院1区4篇，2区2篇。主持国家自然科学基金青年项目和安徽医科大学人才启动基金。

1. 国家自然科学基金，青年项目，基于单细胞测序和靶标垂钓探索山梗菜碱靶向MAPK14调节巨噬细胞极化抑制结肠癌的分子机制，82304799, 2024.01-2026.12,主持。

2. 2024年引进人才科研启动经费，2024.11-2029.11，主持。

3. 国家自然科学基金，联合基金，内质网应激蛋白MANF通过与过氧化还原酶6相互作用调节肝细胞的谱系定型及恶性转化研究，U21A20345，2022/01-2025/12，参与。

1. Mingxia Zhao^#, Lisha Zhou^#, Qinchang Zhang^#, Meijing Wang, Yue Dong, Yue Wang,Ruixue Pei, Enguang He, Yanyan Liang, Yujun Shen, Guoliang Deng, Hongqi Chen, Dongdong Sun,* Yuxian Shen,* Yang Sun,* and Haibo Cheng*.Targeting MAPK14 by Lobeline upregulates Slurp1-mediated inhibition of alternative activation of TAM and retards colorectal cancer growth. Advanced Science,2025. DOI: 10.1002/advs.202407900.

2. Mingxia Zhao^#, Wenjie Guo ^#, Yuanyuan Wu ^#, Chenxi Yang, Liang Zhong , Guoliang Deng,Yuyu Zhu, Wen Liu, Yanhong Gu, Yin Lu, Lingdong Kong, Xiangbao Meng *, Qiang Xu *, Yang Sun*.SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade. Acta pharmaceutica Sinica B, 2019;9(2):304-315.

3. Mingxia Zhao, Bing Zhou, Li Ling, Xiaoqing Xiong, Feng Zhang, Qi Chen,Yuehua Li,Yuming Kang, Guoqing Zhu*. Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy. Cell Death and Disease, 2017;8(3):e2690.

4. Mingxia Zhao ^#, Lihong Shen ^#, Zijun Ouyang ^#, Manru Li, Guoliang Deng,Chenxi Yang, Wei Zheng, Lingdong Kong, Xuefeng Wu, Xudong Wu, Wenjie Guo, Ye Yin *, Qiang Xu *, Yang Sun*. Loss of hnRNP A1 in murine muscle exacerbates high fat diet-induced onset of insulin resistance and hepatic steatosis. Journal of Molecular Cell Biology, 2018;12(4):277-290.

5. Mingxia Zhao ^# , Chenglin Song, Qin-chang Zhang, Haojie Du, Shuqiong Zhang, Yuxian Shen,Yang Sun*, Haibo Cheng*, Wen Lv*.Research on Network Pharmacology of Xian-Lian-Jie-Du Decoction in Ameliorating Colorectal Cancer. World Journal of Traditional Chinese Medicine, 2024;10:83-92.

6. Jian Gao ^#, Zhigui Wu ^#, Mingxia Zhao ^#, Rui Zhang, Manru Li, Dongdong Sun, Haibo Cheng, Xianjia Qi, Yuxian Shen, Qiang Xu*, Hongqi Chen*, Dijun Chen*, Yang Sun*. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell tranomics, Acta Pharmaceutica Sinica B, 2022; 12(1): 149-166.